Melbourne (ANI): Dannii Minogue is desperate to experience John Mayer as her boyfriend. The Aussie isaac M. Singer, who is the sister of Kylie Minogue, has revealed that she became attracted to Mayer when she sawing machine him perform, and is delighted that the 'No Such Thing' hitmaker has split from Jennifer Aniston.
"The best news I've heard for a long time is that John Mayer is single. I wouldn't have given him a second glance, only all that changed when I saw him perform live on TV recently with his top cancelled. I had to be calmed down!" the Daily Telegraph quoted her as telling Showbizspy.com.
"So I am putt it out there - John Mayer, I am going to hunt you down! One woman's scrap is some other woman's treasure!" she added.
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Sunday 31 August 2008
Thursday 21 August 2008
Ex-Bush Aide: 'Swing Vote' Stolen from Him
A former presidential aide claims in a case that plot and marketing elements of the Kevin Costner and Kelsey Grammer movie "Swing Vote" were stolen from him. (AP Photo)More Photos
Political commentator Bradley Blakeman, a former deputy assistant to President Bush for appointments and programing, said in the case filed Thursday that he gave a copyrighted screenplay entitled "Go http://abcnews.go.com/Entertainment/November" to Grammer in 2006.
The lawsuit, filed in federal homage on Long Island, claims Grammer agreed to make grow the project and star as an incumbent Republican president just ended up portraying a similar persona in "Swing Vote," which was released Aug. 1.
A spokesman for Grammer and his production company, both named in the causa, dismissed the claims as frivolous.
"I am not sure why Kelsey was even named in this suit," spokesman Stan Rosenfield wrote in an e-mail. "He was an actor wHO signed on to the project AFTER the handwriting was written."
Blakeman's lawsuit, however, claims the former "Cheers" and "Frasier" actor told him to consult a producer wHO later told him repeatedly that they were interviewing potential screenwriters and aforethought to go ahead with the project.
The lawsuit claims Blakeman's screenplay shared a basic premise with "Swing Vote," although it focused on an election hinging on multiple swing voters instead of one swing voter.
Blakeman claims "Swing Vote" incorporated other elements that he proposed, including: the timing of the film's release, the use of real-life newscasters as actors playing themselves, the economic consumption of dirty tricks by both major political parties, marketing strategies and other plot points.
"Essentially, except for the character names and the relationship developed between the independent characters played by suspect Kevin Costner and his daughter, the entire concept of 'Swing Vote' ... was taken from the copyrighted work," Blakeman's lawsuit claims.
The Walt Disney Co. is named as a defendant in the suit, as is Walt Disney Motion Pictures Group Inc. and Disney division Touchstone Pictures, which distributed "Swing Vote." Costner and the writers of "Swing Vote" also are among those named.
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Monday 11 August 2008
Cake
Artist: Cake
Genre(s):
ROck: Alternative
Rock
Discography:
Comfort Eagle
Year: 2001
Tracks: 11
Fashion Nugget
Year: 1996
Tracks: 14
Motorcade of Generosity
Year: 1994
Tracks: 13
Best-known for their ubiquitous attain "The Distance," Cake epitomized the postmodern, irony-drenched esthetic of ‘90s geek-rock. Their healthy freely miscellaneous and matched pastiches of widely variable genres -- white-boy casimir Funk, rap, country, new wave pop, jazz, college rock candy, and guitar sway -- with a particular please in the clashes that resulted. Their songs were filled with lyrical not sequiturs, pop-culture references, and smirky irony, all delivered with os dry detachment by speak-singing frontman John McCrea. Cake's music most oftentimes earned comparisons to Soul Coughing and King Missile, merely lacked the downtown New York artiness of those two predecessors; or else, Cake cultivated an mental image of fair guys with no illusions or pretensions about their persona as entertainers. At the same time, critics lambasted what they saw as a smugly superior attitude slow the band's habitual irony. Perhaps in that respect was something in Cake's tenaciously spare, low-keyed presentation that amplified their ironical disengagement even when they didn't show it, but most reviewers pegged them as one-hit wonders after the success of "The Distance." Nonetheless, Cake managed a few more than alternative-radio hits in the age that followed, spell retaining largely the same approaching. Cake was formed in Sacramento, California in 1992 by vocalist/songwriter John McCrea, who'd recently returned family later disbursal a few old age in Los Angeles, unsuccessfully trying to break into the music byplay. The original batting order of Cake besides featured guitar role player Greg Brown, trumpeter Vince DiFiore, bassist Sean McFessel, and drummer Frank French; McFessel earlier long left hand to advert college, and was replaced by Gabe Nelson. In 1993, the band released their debut single, "Rock ‘n' Roll Lifestyle," on a local cornerstone, and followed it with a self-generated, self-released, self-distributed album, Motorcade of Generosity. Motorcade set up its path to the revived Capricorn label, which released the record album nationally after Cake signing a contract with them. With the aspect of broad national touring, both Gabe Nelson and Frank French left field the band, and were replaced by bassist Victor Damiani and drummer Todd Roper. Re-released by Capricorn, "Rock ‘n' Roll Lifestyle" caught on at college wireless in 1995, and was followed by 2 more singles, "Ruby Sees All," and "Jolene" (non the Dolly Parton song). Cake's instantaneous record album, Style Nugget, was released in 1996 and spawned a break ruin in the Greg Brown-penned "The Distance," which henpecked alternative receiving congeal that fall, and spirit level turned into an unlikely sporting-event hymn. Mostly on the military capability of "The Distance," Fashion Nugget charted in the Top 40 and sold o'er a 1000000 copies. It besides spun cancelled a somewhat controversial followup individual in a cover of Gloria Gaynor's "I Will Survive"; although the band professed its sincere wonder for the sung dynasty, some critics and listeners took it as a soapy put down, in portion because of McCrea's dead cooking pan vocals. In 1997, Greg Brown and Victor Damiani both left hand Cake and formed a new radical, the raw wave-influenced Deathray, which finally released its debut record album on Capricorn in 2000. Meanwhile, McCrea briefly considered putting Cake to pillow, only brought original bassist Gabe Nelson plump for to assign back Damiani. For Cake's succeeding record album, McCrea secondhand a tag-team forth motion of guitarists -- five in all -- on different tracks; the final result, Prolonging the Magic, was released in 1998. True to its sardonic title, it defied critical opinion to bring forth some other big alternative-radio hit in "Ne'er There," asset decently successful follow-ups in "Sheep Go to Heaven" and "Permit Go." Prolonging the Magic sold intimately as well as Fashion Nugget, and was as well qualified platinum. For the encouraging hitch, unitary of the album's guitarists, Xan McCurdy, officially united Cake full-time. In the natural springiness of 2000, Cake sign a new conduct with Columbia, and debuted in 2001 with their fourth overall record album, Comforter Eagle, which became their highest-charting quiet (at Number 13). The lead individual "Short Skirt/Long Jacket" was a bump off on alternative wireless, and regular earned some MTV airplay -- no yearner an easy project for any creative person -- with a video that featured reactions to the sung dynasty by every which way selected people on the street. Following the pass completion of the record album, drummer Todd Roper left the mathematical group to spend more than time with his children, and was replaced on the supporting spell by Pete McNeal.
Wednesday 6 August 2008
Research Team Creates Human ALS Motor Neurons: First Disease-Specific Stem Cells From Human Skin Cells
�A team of researchers from the Harvard Stem Cell Institute (HSCI) and Columbia University, in a collaboration catalyzed by the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, has demonstrated that pluripotent stem cells generated from a affected role with ALS (amyotrophic lateral sclerosis) canful be directed to mark into motor neurons - the very brain cells destroyed by ALS. The results of the team's study seem in the online issue of Science. This is the first published story to exhibit that disease-specific stem cells may be derived from an individual patient.
In the study, lED by Kevin Eggan, of the Harvard Stem Cell Institute, skin cells taken from a patient with a familial form of ALS were induced to become pluripotent stem cells. Scientists then differentiated the pluripotent cells into motor neurons and glia (accompaniment cells in the brainpower) that featured an ALS genotype.
"This is a seminal discovery," aforesaid Valerie Estess, director of research for Project A.L.S. "The ability to infer ALS motor neurons through a simple skin biopsy opens the doors to improved dose discovery. For the first time, researchers will be able to look at ALS cells under a microscope and see wherefore they die. If we can figure out how a person's motor neurons die, we will design out how to lay aside motor neurons."
Starting in 1999, Project A.L.S. recruited preeminent scientists and clinicians to define the potential office of stem turn cells in understanding and treating ALS, the fatal neurodegenerative disease, also known as Lou Gehrig's disease. Project A.L.S.-funded scientists began by transplant stem cells directly into mice with ALS, with limited success. More recent experiments have shown that stem cells may be more valuable as tools to empathize the disease process and create mini-representations of disease - or assays - for the purpose of drug screening.
"For the low time, we have the opportunity to examine cellular and molecular defects in motor neurons and glial cells derived from patients with ALS. And we can now begin drug screens on disease-specific classes of human motor neurons," said Thomas Jessell, a Howard Hughes Investigator at Columbia University, and Project A.L.S. advisor. "Through the work of the Jenifer Estess Laboratory for Stem Cell Research we today can coup d'oeil the new age of ALS research, an age of advancement and promise."
Co-author on the paper, Christopher Henderson, wHO is co-director of the Columbia University Center for Motor Neuron Biology and Disease, and senior scientific advisor to the Project A.L.S. Laboratory, said: "It has been a prerogative to collaborate with Kevin Eggan and his team and to contribute to this critical step forward. We will continue to work hand in hand with Harvard researchers and Project A.L.S. to exploit the potentiality of these cells for drug screening".
Three years agone, Project A.L.S. asked Dr. Eggan, a stem cell expert, and Chris Henderson, Hynek Wichterle, as government on motor neuron biology and do drugs screening at Columbia University, to work together to understand ALS, one of our most complicated and devastating neurologic disorders. This publication simon Marks the first major breakthrough of this collaboration.
Project A.L.S. is a non-profit 501�3 whose missionary station is to understand, treat, and cure ALS, as well known as Lou Gehrig's disease. The hallmark of the company's approach is collaboration betwixt researchers and clinicians, many of whom have not focused on ALS specifically, or worked together before. In ten-spot years, Project A.L.S. has raised over $37 one thousand thousand for research worldwide. Located in New York, the Project A.L.S./Jenifer Estess Laboratory for Stem Cell is the world's only privately funded science lab to focus exclusively on stem cell and ALS. The testing ground was named for Project A.L.S. founder Jenifer Estess, who died from ALS in 2003.
Source: Patricia Harrington
PROJECT A.L.S.
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In the study, lED by Kevin Eggan, of the Harvard Stem Cell Institute, skin cells taken from a patient with a familial form of ALS were induced to become pluripotent stem cells. Scientists then differentiated the pluripotent cells into motor neurons and glia (accompaniment cells in the brainpower) that featured an ALS genotype.
"This is a seminal discovery," aforesaid Valerie Estess, director of research for Project A.L.S. "The ability to infer ALS motor neurons through a simple skin biopsy opens the doors to improved dose discovery. For the first time, researchers will be able to look at ALS cells under a microscope and see wherefore they die. If we can figure out how a person's motor neurons die, we will design out how to lay aside motor neurons."
Starting in 1999, Project A.L.S. recruited preeminent scientists and clinicians to define the potential office of stem turn cells in understanding and treating ALS, the fatal neurodegenerative disease, also known as Lou Gehrig's disease. Project A.L.S.-funded scientists began by transplant stem cells directly into mice with ALS, with limited success. More recent experiments have shown that stem cells may be more valuable as tools to empathize the disease process and create mini-representations of disease - or assays - for the purpose of drug screening.
"For the low time, we have the opportunity to examine cellular and molecular defects in motor neurons and glial cells derived from patients with ALS. And we can now begin drug screens on disease-specific classes of human motor neurons," said Thomas Jessell, a Howard Hughes Investigator at Columbia University, and Project A.L.S. advisor. "Through the work of the Jenifer Estess Laboratory for Stem Cell Research we today can coup d'oeil the new age of ALS research, an age of advancement and promise."
Co-author on the paper, Christopher Henderson, wHO is co-director of the Columbia University Center for Motor Neuron Biology and Disease, and senior scientific advisor to the Project A.L.S. Laboratory, said: "It has been a prerogative to collaborate with Kevin Eggan and his team and to contribute to this critical step forward. We will continue to work hand in hand with Harvard researchers and Project A.L.S. to exploit the potentiality of these cells for drug screening".
Three years agone, Project A.L.S. asked Dr. Eggan, a stem cell expert, and Chris Henderson, Hynek Wichterle, as government on motor neuron biology and do drugs screening at Columbia University, to work together to understand ALS, one of our most complicated and devastating neurologic disorders. This publication simon Marks the first major breakthrough of this collaboration.
Project A.L.S. is a non-profit 501�3 whose missionary station is to understand, treat, and cure ALS, as well known as Lou Gehrig's disease. The hallmark of the company's approach is collaboration betwixt researchers and clinicians, many of whom have not focused on ALS specifically, or worked together before. In ten-spot years, Project A.L.S. has raised over $37 one thousand thousand for research worldwide. Located in New York, the Project A.L.S./Jenifer Estess Laboratory for Stem Cell is the world's only privately funded science lab to focus exclusively on stem cell and ALS. The testing ground was named for Project A.L.S. founder Jenifer Estess, who died from ALS in 2003.
Source: Patricia Harrington
PROJECT A.L.S.
More info
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